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Plot : It is the mid 1990s. Jamie (Jake Gyllenhall) is seen working in an electronics store. Hes talking females of all ages into buying phones and stereos while flirting with the store owner's girlfriend. Jamie and the owner's girlfriend sneak into the back to have sex and she accidentally calls her boyfriend on the intercom phone and he hears them everything. After getting punched in the face by his boss, Jamie runs out of the store (stopping to hit on a woman on the way out).
Later that night, Jamie is at his parents house for dinner. His father and his sister are doctors and his brother, Josh, is rich from owning a medical software company. At dinner, Josh and his wife fight and he brings up Jamie getting fired and the family gets on him for dropping out of med school. Jamie blows them off and brings up that Josh is going to help him get set up as a pharmaceutical sales rep.
With Josh's help, Jamie goes to work for Pfizer, practicing his sales pitch and trying to get doctors to prescribe Zoloft and Zithromax. He is rebuffed constantly by doctors much to the dismay of his partner Bruce (Oliver Platt) who sees Jamie as his ticket to the "big leagues" of Chicago near his wife and kids. Bruce tells Jamie if he can get Dr. Knight (Hank Azaria) to prescribe Zoloft instead of Prozac then all the other doctors will follow his lead. After trying to chat Dr. Knight up several times unsuccessfully, Jamie flirts with his receptionists and sneaks into the back to steal all of the Prozac samples and throw them in the dumpster.
Jamie is still unable to raise his sales so he pays Dr. Knight $1,000 to let him shadow him. The doctor accepts and Jamie spends the day babbling about how Zoloft is better than Prozac.
Dr. Knight goes in to see a patient and tells Jamie to say hes an intern. Knights patient is Maggie (Anne Hathaway) a young woman diagnosed with an early onset of Parkinson's Diease. Maggie tells Jamie that someone broke into her house and stole all her medication and she gives him a long list of refills that she needs. While there, Maggie asks Jamie to look at a weird lump on her breast, which turns out to be a spider bite in which Dr. Knight enters and the gig is up.
Later in the parking lot, Maggie stops Jamie while he is throwing away Prozac and punches him in the face for pretending to be an intern and for looking at her breast. She takes his picture and leaves.
Jamie comes home to find Josh who has split from his wife and wants to stay with him. Jamie calls Dr. Knight's receptionist (who he is sleeping with) and gets Maggies number. He calls Maggie and asks her out for coffee. At first she says no, but then she gives in and meets him. The date is basically him being charming and her being rude. After 10 minutes, they head back to her apartment and have very casual sex. Afterwards, she kicks him out right away and we see a montage of Jamie getting booty calls and him and Maggie having sex everywhere and whenever she calls him.
Later at work, Jamie is throwing away the Prozac pills and he looks up to get punched in the face by Trey (Gabriel Macht), the rep for Prozac. Trey is the top seller in the region and gives the doctors and staff big kickbacks (trips to Florida and Hawaii) for pushing Prozac. He says he knows what Jamie is doing and that he will take him down if he doesn't stop. Trey and Jamie fight some more and he leaves Jamie on the ground after telling him to stay way from Maggie. Jamie then gets take out food and goes to see Maggie.
After briefly discussing Trey (hes married but was seeing her on the side) and Maggie's Parkinsons (shes a waitress and has no health insurance) they start to have sex but Jamie is unable to get errect for the occasion. After a few kind words from Maggie, they just hang out and she teases him that he should use the new erection drug that his company has developed. The next day before Jamie leaves, Maggie begins having problems with tremors, which she hides from him as she pushes him out the door. Jamie approaches Bruce about the new drug and Bruce says he will look into it.
At work, Jamie gets the green light to sell Viagra and suddenly he is extremely popular and the doctors pursue him.
Back at his apartment, Maggie and Jamie talk and he tries to convince her to have a relationship with him. She says no and leaves. The next day, Maggie is helping senior citizens onto a bus to go to Canada to get cheap prescription drugs when Jamie shows up. They argue about their relationship some more and she leaves. Jamie waits in the parking lot for her to come back and the next day when the bus comes back Maggie is touched that he waited. Maggie tells him that she will have a relationship with him but that she gets to hate him and slam him to her girlfriends when he dumps her.
Back at her apartment, Maggie talks about how she use to be a painter but since her diagnosis with Parkinsons, she has switched to photography/collages. Jamie talks about how he dropped out of med school because he has ADD (Attention Deficit Disorder).
One night after networking at the bar, Jamie comes home and starts to mess around with Maggie when he starts to hyper ventilate and tells her that he loves her and that she is the first person he has ever told that to.
A few days later, Bruce and Jamie are talking about an upcoming conference in Chicago and Jamie says he doesn't want to leave Maggie to go because of her illness. Jamie comes home to find Maggie drunk. Earlier in the day, she realized that she ran out of meds and couldnt get to the pharmacy in time to get a refill due to the wait in the clinic. They have a fight and Jamie leaves. After he walks out, Maggie starts to cry and throws her glass. Jamie comes back and holds her and they make up.....
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